Hippocampal sclerosis of aging in NACC

 
   Lead Investigator:    Peter Nelson
   Institution      :    U Kentucky
   E-Mail           :    pnels2@uky.edu
   Proposal ID      :    269


   Publications:


1  Brenowitz WD, Monsell SE, Kukull WA , Nelson PT
   Hippocampal sclerosis of aging, a key potential AD confounder: the NACC experience
   Abstract  Alzheimers Dement,9:P542,2013,

   PUBLISHED



2  Brenowitz WD, Monsell SE , Schmitt FA,  Kukull WA , Nelson PT
   Hippocampal sclerosis of aging is a key Alzheimer's disease mimic: clinical-pathologic correlations and comparisons with both alzheimer's disease and non-tauopathic frontotemporal lobar degeneration
   Journal Article  J Alzheimers Dis,39:691-702,2014,PMC3946156

   PUBLISHED



3  Katsumata Y, Nelson PT, Ellingson SR, Fardo DW
   Genetic Association of the ABCC9 Gene with Hippocampal Sclerosis of Aging Neuropathology
   Abstract  Innov Aging,1:255,2017,

   PUBLISHED



4  Nelson PT, Katsumata Y, Nho K, Artiushin SC, Jicha GA, Wang W, Abner EL, Saykin AJ,  Kukull WA , Fardo DW
   Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging
   Journal Article  Acta Neuropathol,132:841-858,2016,PMC5154615

   PUBLISHED



5  Neltner JH, Abner EL, Baker S, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Hammack E,  Kukull WA, Brenowitz WD , Van Eldik LJ, Nelson PT
   Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing
   Journal Article  Brain,137:255-267,2014,PMC3891448

   PUBLISHED





   Proposal Description:
   Update 5/2020: We are seeking to analyze NP v10 data (related to HS and brain arteriolosclerosis) for this project as well.     The objective of this study is to describe the correlation of hippocampal sclerosis (HS) pathology with age, cerebrovascular pathologies, AD pathology, APOE genotype, and cognitive status. Trends in the neuropathological and clinical diagnosis of HS will also be explored. This study will somewhat extend recent research on HS (Nelson et al.,) to all NACC NP data on UDS subjects.